The percentage of people who develop melanoma has more than doubled in the past 30 years, in the United States.
- Ten percent of all people with melanoma have a family history of melanoma.
- Non-Hispanic whites have the highest incident rate of melanoma with 28 cases per 100,000 people.
- 7 per 100,000 in American Indians/Alaska Natives.
- 5 per 100,000 in Hispanics.
- 1 per 100,000 in non-Hispanic blacks and Asians/Pacific Islanders populations.
In 2023, it is estimated that:
- There will be 186,680 cases of melanoma diagnosed, with 89,070 noninvasive cases (in situ) and 97,610 invasive cases. Of the invasive cases,
- 58,120 cases will occur in men.
- 39,490 cases will occur in women.
- There will be 7,990 deaths from the disease.
- 5,420 will be men.
- 2,570 will be women.
FDA recommends use of broad spectrum sunscreen with sun protection factor (SPF) values of 15 or higher, even on cloudy days.
OTC sunscreen monograph establishes the conditions under which the FDA permits these products to be marketed without approved new drug applications, because they are generally recognized as safe and effective (GRASE), and not misbranded.
Two ingredients – zinc oxide and titanium dioxide – are GRASE for use in sunscreens. However, two ingredients – PABA and trolamine salicylate – are not GRASE for use in sunscreens due to safety issues.
Products that combine sunscreens with insect repellents are not generally recognized as safe and effective (GRASE).
OTC internal analgesics include the following active ingredients: acetaminophen, aspirin, ibuprofen, ketoprofen, and naproxen sodium.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are medicines used to temporarily treat minor to moderate pain and inflammation related to everything from arthritis, muscle aches, backaches, headaches, toothaches, sprains, strains, and menstrual cramps. They can also be used to reduce flu or common cold fevers and body aches.
NSAIDs are one of two major types of oral over-the-counter (OTC) pain relievers, the other being acetaminophen. Acetaminophen is in more than 600 over-the-counter (OTC) and prescription (Rx) medicines.
According to the FDA, unintentional overdoses represent a very low portion of serious adverse events. The overwhelming majority of fatalities related to acetaminophen overdose (83 percent for Rx and 84 percent for OTCs) are intentional suicides.
An OTC Monograph is a “rule book” for each therapeutic category establishing conditions, such as active ingredients, uses (indications), doses, route of administration, labeling, and testing under which an OTC drug is generally recognized as safe and effective (GRASE).